Target Information

General Information of This Target
Target ID
BTDT00098
Target Name
Caveolin-2 (CAV2)
Target Bioclass
Transporter and channel
Uniprot ID
P51636
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
CAV2
Gene ID
858
Sequence
MGLETEKADVQLFMDDDSYSHHSGLEYADPEKFADSDQDRDPHRLNSHLKLGFEDVIAEP
VTTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFIAGILFATLSCLHIWILMPFVK
TCLMVLPSVQTIWKSVTDVIIAPLCTSVGRCFSSVSLQLSQD

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Family
the caveolin family
Function
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.

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Taxonomy ID
9606
TCDB ID
8.A.104.1.11
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Conotoxin Vr3a Inhibition rate
12.86 %
 [1], [2]
 Toxin Info    Omega-conotoxin MoVIA IC50
330 nM
 [3]
 Toxin Info    Omega-theraphotoxin-Avsp1a IC50
>25 μM
 [4]
 Toxin Info    Beta-theraphotoxin-Cd1a IC50
˜3 μM
 [5]
References
Ref 1 Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon. 2013 Dec 15;76:150-9. doi: 10.1016/j.toxicon.2013.09.020. Epub 2013 Sep 27.
Ref 2 A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents. J Venom Anim Toxins Incl Trop Dis. 2021 Jun 11;27:e20200164. doi: 10.1590/1678-9199-JVATITD-2020-0164. eCollection 2021.
Ref 3 Novel analgesic -conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.
Ref 4 The Tarantula Toxin -Avsp1a Specifically Inhibits Human Ca(V)3.1 and Ca(V)3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor. Biomedicines. 2022 May 4;10(5):1066. doi: 10.3390/biomedicines10051066.
Ref 5 Discovery and mode of action of a novel analgesic -toxin from the African spider Ceratogyrus darlingi. PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.
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