Peptide Information

General Information of This Peptide
Peptide ID
BTDP008909
Peptide Name
Kcug1 (C1V,T2K,A3C,S4T,K5A,Q6S,C7K,W8Q,P9C,V10W,C11P,N12V,Q13C,M14N,F15Q,G16M,K17F,P18G,N19K,G20P,K21N,C22G,M23K,N24C,G25M,K26N,C27G,R28K)
Symonym
Kcug1 (C1V,T2K,A3C,S4T,K5A,Q6S,C7K,W8Q,P9C,V10W,C11P,N12V,Q13C,M14N,F15Q,G16M,K17F,P18G,N19K,G20P,K21N,C22G,M23K,N24C,G25M,K26N,C27G,R28K)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
CTASKQCWPVCNQMFGKPNGKCMNGKCRC
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Mutant Sequence
VKCTASKQCWPVCNQMFGKPNGKCMNGKCRCY
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Sequence Length
32
Mass(Da)
3608
Sequence Removed Signal Peptide
VKCTASKQCWPVCNQMFGKPNGKCMNGKCRCY
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate
1.6 %
1 μM
Blocker
 [1]
 Target Info    Kv1.2 IC50
89.9 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
1.1424 μM
 .
Blocker
 [1]
References
Ref 1 Different pharmacological properties between scorpion toxin BmKcug2 and its degraded analogs highlight the diversity of K(+) channel blockers from thermally processed scorpions. Int J Biol Macromol. 2021 May 1;178:143-153. doi: 10.1016/j.ijbiomac.2021.02.155. Epub 2021 Feb 23.
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