Peptide Information

General Information of This Peptide
Peptide ID
BTDP008890
Peptide Name
Venom basic protease inhibitor 1 homolog (L3R,Q18D,G34R,T36D,R59G)
Symonym
Venom basic protease inhibitor 1 homolog (L3R,Q18D,G34R,T36D,R59G)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
QPRRKLCILHRNPGRCYDKIPAFYYNQKKKQCERFDWSGCGGNSNRFKTIEECRRTCIG
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Mutant Sequence
QPRRKLCILHRNPGRCYDKIPAFYYNQKKKQCERFDWSGCGGNSNRFKTIEECRRTCIG
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Sequence Length
59
Mass(Da)
7172
Sequence Removed Signal Peptide
QPRRKLCILHRNPGRCYDKIPAFYYNQKKKQCERFDWSGCGGNSNRFKTIEECRRTCIG
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Disulfide Bond
7-40;16-53;32-57
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv Dissociation constant
5 pM
 .
Inhibitor
 [1]
 Target Info    Kv1.2 Dissociation constant
0.012 nM
 .
Inhibitor
 [2]
 Target Info    Kv1.1 Dissociation constant
0.024 nM
 .
Inhibitor
 [2]
 Target Info    Kv1.6 Dissociation constant
0.037 nM
 .
Inhibitor
 [2]
 Target Info    Kv Dissociation constant
0.3 nM
 .
Inhibitor
 [3]
 Target Info    Kv Dissociation constant
0.5 nM
 .
Inhibitor
 [4]
References
Ref 1 Delineation of the functional site of alpha-dendrotoxin. The functional topographies of dendrotoxins are different but share a conserved core with those of other Kv1 potassium channel-blocking toxins. J Biol Chem. 1998 Sep 25;273(39):25393-403. doi: 10.1074/jbc.273.39.25393.
Ref 2 Characterization of a novel radiolabeled peptide selective for a subpopulation of voltage-gated potassium channels in mammalian brain. J Biol Chem. 2002 Feb 8;277(6):3886-93. doi: 10.1074/jbc.M109886200. Epub 2001 Nov 13.
Ref 3 Involvement of neuronal acceptors for dendrotoxin in its convulsive action in rat brain. Biochem J. 1986 Jul 15;237(2):397-404. doi: 10.1042/bj2370397.
Ref 4 Solubilization and physical characterization of acceptors for dendrotoxin and beta-bungarotoxin from synaptic membranes of rat brain. Biochemistry. 1988 Sep 6;27(18):6814-20. doi: 10.1021/bi00418a025.
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