Peptide Information

General Information of This Peptide
Peptide ID
BTDP008769
Peptide Name
SsTx-4 (K45A)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
EVIKRDIPFKKRKFPYKSECLKACATSFTGGDESRIQEGKPGFFKCTCYFTTG
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Mutant Sequence
EVIKRDIPFKKRKFPYKSECLKACATSFTGGDESRIQEGKPGFFACTCYFTTG
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Sequence Length
53
Mass(Da)
5985
Sequence Removed Signal Peptide
EVIKRDIPFKKRKFPYKSECLKACATSFTGGDESRIQEGKPGFFACTCYFTTG
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Disulfide Bond
20-46;24-28
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kir6.2 IC50
49.2 nM
 .
Blocker
 [1]
 Target Info    Kir1.1 IC50
178.4 nM
 .
Blocker
 [1]
 Target Info    Kir4.1 IC50
360 nM
 .
Blocker
 [1]
References
Ref 1 Molecular mechanisms of centipede toxin SsTx-4 inhibition of inwardly rectifying potassium channels. J Biol Chem. 2021 Sep;297(3):101076. doi: 10.1016/j.jbc.2021.101076. Epub 2021 Aug 12.
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