Target Information

General Information of This Target
Target ID
BTDT00093
Target Name
ATP-sensitive inward rectifier potassium channel 1 (KCNJ1)
Target Bioclass
Transporter and channel
Uniprot ID
P48048
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
KCNJ1
Gene ID
3758
Synonym
ROMK1; ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; Potassium channel, inwardly rectifying subfamily J member 1
Sequence
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM

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Family
the inward rectifier-type potassium channel family
Function
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.

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Taxonomy ID
9606
TCDB ID
1.A.2.1.1
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    SsTx-4 (Y16A) IC50
30.4 nM
 [1]
 Toxin Info    SsTx-4 (R12A) IC50
39.1 nM
 [1]
 Toxin Info    SsTx-4 (Y49A) IC50
60 nM
 [1]
 Toxin Info    Mu-SLPTX (15)-Ssm1a (K5R,T7I,Y97) IC50
89.2 nM
 [1]
 Toxin Info    SsTx-4 (F43A) IC50
89.2 nM
 [1]
 Toxin Info    SsTx-4 (P41A) IC50
89.2 nM
 [1]
 Toxin Info    SsTx-4 (P8A) IC50
89.2 nM
 [1]
 Toxin Info    SsTx-4 (P15A) IC50
159.7 nM
 [1]
 Toxin Info    SsTx-4 (K10A) IC50
178.4 nM
 [1]
 Toxin Info    SsTx-4 (K40A) IC50
178.4 nM
 [1]
 Toxin Info    SsTx-4 (K45A) IC50
178.4 nM
 [1]
 Toxin Info    SsTx-4 (K4A) IC50
178.4 nM
 [1]
 Toxin Info    SsTx-4 (K17A) IC50
178.4 nM
 [1]
 Toxin Info    SsTx-4 (K40A,K45A) IC50
356.8 nM
 [1]
 Toxin Info    SsTx-4 (F9A) IC50
446 nM
 [1]
 Toxin Info    SsTx-4 (K4A,K45A) IC50
446 nM
 [1]
 Toxin Info    SsTx-4 (K4A,K40A) IC50
535.2 nM
 [1]
 Toxin Info    SsTx-4 (K11A) IC50
561.2 nM
 [1]
 Toxin Info    SsTx-4 (F43A,F44A) IC50
713.6 nM
 [1]
 Toxin Info    SsTx-4 (F44A) IC50
981.2 nM
 [1]
 Toxin Info    SsTx-4 (K4A,K40A,K45A) IC50
981.2 nM
 [1]
 Toxin Info    SsTx-4 (F14A) IC50
1.2488 μM
 [1]
 Toxin Info    SsTx-4 (K13A) IC50
5.6196 μM
 [1]
References
Ref 1 Molecular mechanisms of centipede toxin SsTx-4 inhibition of inwardly rectifying potassium channels. J Biol Chem. 2021 Sep;297(3):101076. doi: 10.1016/j.jbc.2021.101076. Epub 2021 Aug 12.
Ref 2 A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel. J Gen Physiol. 2018 Jul 2;150(7):969-976. doi: 10.1085/jgp.201812017. Epub 2018 May 29.
Ref 3 Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin. Biochemistry. 2006 Aug 22;45(33):10129-39. doi: 10.1021/bi060509s.
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