Peptide Information

General Information of This Peptide
Peptide ID
BTDP008738
Peptide Name
Potassium channel toxin ShK ([pTyr][AEEA])
Symonym
Potassium channel toxin ShK ([pTyr][AEEA])
3D Structure
Original Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Mutant Sequence
[pTyr][AEEA]RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Sequence Length
37
Mass(Da)
4443
Sequence Removed Signal Peptide
[pTyr][AEEA]RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Disulfide Bond
5-30;14-34;19-37
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
0.069 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 Dissociation constant
7 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 Dissociation constant
18 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 Dissociation constant
115 nM
 .
Blocker
 [1]
 Target Info    Kv1.4 Dissociation constant
137 nM
 .
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
100 nM
Blocker
 [2]
 Target Info    KCa2.1 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
100 nM
Blocker
 [2]
 Target Info    Kir2.1 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.06899 nM
 .
Blocker
 [3]
 Target Info    Kv1.3 IC50
0.069 nM
 .
Blocker
 [2]
 Target Info    Kv1.3 IC50
0.071 nM
 .
Blocker
 [2]
 Target Info    Kv3.2 IC50
20 nM
 .
Blocker
 [2]
References
Ref 1 Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr;67(4):1369-81. doi: 10.1124/mol.104.008193. Epub 2005 Jan 21.
Ref 2 Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol. 2009 Apr;75(4):762-73. doi: 10.1124/mol.108.052704. Epub 2009 Jan 2.
Ref 3 Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease. J Pharmacol Exp Ther. 2012 Sep;342(3):642-53. doi: 10.1124/jpet.112.191890. Epub 2012 May 25.
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