Peptide Information

General Information of This Peptide
Peptide ID
BTDP008723
Peptide Name
Beta-defensin 104
Symonym
Beta-defensin 4; Defensin, beta 104
Species
Homo sapiens (Human)
Uniprot Name
D104A_HUMAN
Alphafold ID
Q8WTQ1
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 5KI9
Sequence
MQRLVLLLAISLLLYQDLPVRSEFELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLR
KWDESLLNRTKP
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Sequence Length
72
Mass (Da)
8526
Sequence Removed Signal Peptide
EFELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP
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Disulfide Bond
30-57;37-51;41-58
PDB ID
5KI9
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate
19 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
34 %
1 μM
Blocker
 [1]
References
Ref 1 Pharmacological characterization of human beta-defensins 3 and 4 on potassium channels: Evidence of diversity in beta-defensin-potassium channel interactions. Peptides. 2018 Oct;108:14-18. doi: 10.1016/j.peptides.2018.08.005. Epub 2018 Aug 16.
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