Peptide Information

General Information of This Peptide
Peptide ID
BTDP008715
Peptide Name
Potassium channel toxin alpha-KTx 6.1
Symonym
PiTX-K-gamma; Potassium channel-blocking toxin 1
Species
Pandinus imperator (Emperor scorpion)
Uniprot Name
KAX61_PANIM
Alphafold ID
Q10726
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1WZ5
Sequence
LVKCRGTSDCGRPCQQQTGCPNSKCINRMCKCYGC
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Sequence Length
35
Mass (Da)
3843
Sequence Removed Signal Peptide
LVKCRGTSDCGRPCQQQTGCPNSKCINRMCKCYGC
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Disulfide Bond
4-25;10-30;14-32;20-35
PDB ID
1WZ5
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Pandinus
Species: Pandinus imperator
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
9.7 nM
 .
Blocker
 [1]
 Target Info    Shaker Dissociation constant
32 nM
 .
Blocker
 [2]
 Target Info    KCa2.3 Dissociation constant
330 nM
 .
Blocker
 [1- 9]
 Target Info    KCa2.3 Dissociation constant
330 nM
 .
Blocker
 [6]
 Target Info    KCa2.2 Dissociation constant
>1 μM
 .
Blocker
 [1- 9]
 Target Info    KCa2.2 Inhibition rate .
1 μM
Blocker
 [6]
 Target Info    Kv1.1 Inhibition rate .
5 μM
Blocker
 [1- 9]
 Target Info    Kv1 Inhibition rate .
5 μM
Blocker
 [5]
 Target Info    Kv1.2 IC50
0.44 nM
 .
Blocker
 [1- 9]
 Target Info    Kv1.2 IC50
0.44 nM
 .
Blocker
 [1- 9]
 Target Info    Kv1 IC50
100 nM
 .
Blocker
 [1- 9]
References
Ref 1 Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes. Biochem Biophys Res Commun. 1998 Jan 26;242(3):621-5. doi: 10.1006/bbrc.1997.8018.
Ref 2 Block of ShakerB K+ channels by Pi1, a novel class of scorpion toxin. FEBS Lett. 1997 Jan 3;400(2):197-200. doi: 10.1016/s0014-5793(96)01387-7.
Ref 3 A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator. Biochem J. 1996 May 1;315 ( Pt 3)(Pt 3):977-81. doi: 10.1042/bj3150977.
Ref 4 Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels. Mol Pharmacol. 1996 Nov;50(5):1167-77.
Ref 5 Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels. Eur J Biochem. 2000 Aug;267(16):5149-55. doi: 10.1046/j.1432-1327.2000.01577.x.
Ref 6 Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276(46):43145-51. doi: 10.1074/jbc.M106981200. Epub 2001 Aug 29.
Ref 7 The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem J. 2004 Jan 1;377(Pt 1):25-36. doi: 10.1042/BJ20030115.
Ref 8 A novel potassium channel blocking toxin from the scorpion Pandinus imperator: A 1H NMR analysis using a nano-NMR probe. Biochemistry. 1997 Mar 4;36(9):2649-58. doi: 10.1021/bi9617116.
Ref 9 The impact of the fourth disulfide bridge in scorpion toxins of the alpha-KTx6 subfamily. Proteins. 2005 Dec 1;61(4):1010-23. doi: 10.1002/prot.20681.
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