Peptide Information

General Information of This Peptide
Peptide ID
BTDP008711
Peptide Name
Defensin alpha 5
Symonym
Defensin-5; HD5(20-94)
Species
Homo sapiens (Human)
Uniprot Name
DEF5_HUMAN
Alphafold ID
Q01523
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1ZMP
Sequence
MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQ
ARATCYCRTGRCATRESLSGVCEISGRLYRLCCR
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Sequence Length
94
Mass (Da)
10071
Sequence Removed Signal Peptide
ESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRTGRCATRESLS
GVCEISGRLYRLCCR
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Disulfide Bond
65-93;67-82;72-92
PDB ID
1ZMP , 2LXZ , 2MIT , 3I5W , 4E82 , 4E83 , 4E86 , 4RBW , 4RBX , 5CUI , 5CUJ , 5CUM
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    potassium channels . . .
Blocker
 [1- 14]
 Target Info    potassium channels . . .
Blocker
 [1- 14]
 Target Info    potassium channels . . .
Blocker
 [1- 14]
 Target Info    potassium channels . . .
Blocker
 [15]
 Target Info    KCa3.1 Inhibition rate
5 %
1 μM
Blocker
 [15]
 Target Info    Kv1.2 Inhibition rate
7 %
1 μM
Blocker
 [15]
 Target Info    Kv11 Inhibition rate
9 %
1 μM
Blocker
 [15]
 Target Info    Kv7.1 Inhibition rate
11 %
1 μM
Blocker
 [15]
 Target Info    Kv1.3 IC50
2.2 μM
 .
Blocker
 [15]
References
Ref 1 DNA sequence and analysis of human chromosome 8. Nature. 2006 Jan 19;439(7074):331-5. doi: 10.1038/nature04406.
Ref 2 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. doi: 10.1101/gr.2596504.
Ref 3 Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002 Jun;3(6):583-90. doi: 10.1038/ni797. Epub 2002 May 20.
Ref 4 Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature. 2003 Apr 3;422(6931):522-6. doi: 10.1038/nature01520. Epub 2003 Mar 19.
Ref 5 Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-75. doi: 10.1128/AAC.49.1.269-275.2005.
Ref 6 Human alpha defensin 5 expression in the human kidney and urinary tract. PLoS One. 2012;7(2):e31712. doi: 10.1371/journal.pone.0031712. Epub 2012 Feb 16.
Ref 7 Paneth cell -defensin 6 (HD-6) is an antimicrobial peptide. Mucosal Immunol. 2015 May;8(3):661-71. doi: 10.1038/mi.2014.100. Epub 2014 Nov 5.
Ref 8 Paneth cell -defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3746-3751. doi: 10.1073/pnas.1817376116. Epub 2019 Feb 11.
Ref 9 Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci. 2006 Dec;15(12):2749-60. doi: 10.1110/ps.062336606. Epub 2006 Nov 6.
Ref 10 Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5. FEBS Lett. 2009 Aug 6;583(15):2507-12. doi: 10.1016/j.febslet.2009.06.051. Epub 2009 Jul 7.
Ref 11 NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin 5. Biochemistry. 2012 Dec 4;51(48):9624-37. doi: 10.1021/bi301255u. Epub 2012 Nov 19.
Ref 12 Functional determinants of human enteric -defensin HD5: crucial role for hydrophobicity at dimer interface. J Biol Chem. 2012 Jun 22;287(26):21615-27. doi: 10.1074/jbc.M112.367995. Epub 2012 May 9.
Ref 13 Design of a potent antibiotic peptide based on the active region of human defensin 5. J Med Chem. 2015 Apr 9;58(7):3083-93. doi: 10.1021/jm501824a. Epub 2015 Mar 20.
Ref 14 Human Enteric -Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity. 2018 Jun 19;48(6):1233-1244.e6. doi: 10.1016/j.immuni.2018.04.014. Epub 2018 May 29.
Ref 15 Human -defensins are immune-related Kv1.3 channel inhibitors: new support for their roles in adaptive immunity. FASEB J. 2015 Oct;29(10):4324-33. doi: 10.1096/fj.15-274787. Epub 2015 Jul 6.
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