Peptide Information

General Information of This Peptide
Peptide ID
BTDP008692
Peptide Name
Potassium channel toxin alpha-KTx 1.10
Symonym
Parabutoxin-3
Species
Parabuthus transvaalicus (South African fattail scorpion)
Uniprot Name
KAX1A_PARTR
Alphafold ID
P83112
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P83112
Sequence
EVDMRCKSSKECLVKCKQATGRPNGKCMNRKCKCYPR
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Sequence Length
37
Mass (Da)
4280
Sequence Removed Signal Peptide
EVDMRCKSSKECLVKCKQATGRPNGKCMNRKCKCYPR
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Disulfide Bond
6-27;12-32;16-34
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Parabuthus
Species: Parabuthus transvaalicus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
492 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.3 Dissociation constant
492 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
547 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.2 Dissociation constant
547 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.1 Dissociation constant
79 μM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1 Dissociation constant
79 μM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv11 Inhibition rate .
5 μM
Blocker
 [3]
References
Ref 1 Purification, characterization and biosynthesis of parabutoxin 3, a component of Parabuthus transvaalicus venom. Eur J Biochem. 2002 Apr;269(7):1854-65. doi: 10.1046/j.1432-1033.2002.02833.x.
Ref 2 Evidence for a function-specific mutation in the neurotoxin, parabutoxin 3. Eur J Neurosci. 2003 May;17(9):1786-92. doi: 10.1046/j.1460-9568.2003.02613.x.
Ref 3 A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18.
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