Peptide Information

General Information of This Peptide
Peptide ID
BTDP008688
Peptide Name
Beta-defensin 103
Symonym
Beta-defensin 3; Defensin, beta 103; Defensin-like protein
Species
Homo sapiens (Human)
Uniprot Name
D103A_HUMAN
Alphafold ID
P81534
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1KJ6
Sequence
MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGR
KCCRRKK
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Sequence Length
67
Mass (Da)
7697
Sequence Removed Signal Peptide
GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK
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Disulfide Bond
33-62;40-55;45-63
PDB ID
1KJ6
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate
5 %
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
51 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
187.6 nM
 .
Blocker
 [1]
References
Ref 1 Pharmacological characterization of human beta-defensins 3 and 4 on potassium channels: Evidence of diversity in beta-defensin-potassium channel interactions. Peptides. 2018 Oct;108:14-18. doi: 10.1016/j.peptides.2018.08.005. Epub 2018 Aug 16.
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