Peptide Information

General Information of This Peptide
Peptide ID
BTDP008676
Peptide Name
Potassium channel toxin alpha-KTx 11.1
Symonym
Parabutoxin-1
Species
Parabuthus villosus (Black hairy thick-tailed scorpion)
Uniprot Name
KA111_PARVI
Alphafold ID
P60164
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P60164
Sequence
DEEPKESCSDEMCVIYCKGEEYSTGVCDGPQKCKCSD
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Sequence Length
37
Mass (Da)
4096
Sequence Removed Signal Peptide
DEEPKESCSDEMCVIYCKGEEYSTGVCDGPQKCKCSD
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Disulfide Bond
8-27;13-33;17-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Parabuthus
Species: Parabuthus villosus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
800 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
1 μM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1 Dissociation constant
21 μM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv7.1 Inhibition rate
21.43 %
10 μM
Blocker
 [1], [2], [3]
References
Ref 1 A subfamily of acidic alpha-K(+) toxins. J Biol Chem. 2004 Jan 23;279(4):2781-9. doi: 10.1074/jbc.M311029200. Epub 2003 Oct 14.
Ref 2 A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol Sci. 1999 Nov;20(11):444-7. doi: 10.1016/s0165-6147(99)01398-x.
Ref 3 Structural and functional diversity of acidic scorpion potassium channel toxins. PLoS One. 2012;7(4):e35154. doi: 10.1371/journal.pone.0035154. Epub 2012 Apr 12.
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