Peptide Information

General Information of This Peptide
Peptide ID
BTDP008675
Peptide Name
Beta-defensin 1
Symonym
Defensin, beta 1
Species
Homo sapiens (Human)
Uniprot Name
DEFB1_HUMAN
Alphafold ID
P60022
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1E4S
Sequence
MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCY
RGKAKCCK
   Click to Show/Hide
Sequence Length
68
Mass (Da)
7420
Sequence Removed Signal Peptide
DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK
   Click to Show/Hide
Disulfide Bond
37-66;44-59;49-67
PDB ID
1E4S , 1IJU , 1IJV , 1KJ5 , 2NLB , 2NLC , 2NLD , 2NLE , 2NLF , 2NLG , 2NLH , 2NLP , 2NLQ , 2NLS , 2PLZ
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate
3 %
1 μM
Blocker
 [1]
 Target Info    KCa3.1 Inhibition rate
6 %
1 μM
Blocker
 [1]
 Target Info    KCa2.3 Inhibition rate
9 %
1 μM
Blocker
 [1]
 Target Info    Kv7.1 Inhibition rate
9 %
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
13 %
1 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate
13 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
11.8 μM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
13.2 μM
 .
Blocker
 [1]
References
Ref 1 Human beta-defensin 1, a new animal toxin-like blocker of potassium channel. Toxicon. 2016 Apr;113:1-6. doi: 10.1016/j.toxicon.2016.02.007. Epub 2016 Feb 5.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.