Peptide Information

General Information of This Peptide
Peptide ID
BTDP008669
Peptide Name
Neutrophil defensin 1
Symonym
Defensin, alpha 1; HNP-1
Species
Homo sapiens (Human)
Uniprot Name
DEF1_HUMAN
Alphafold ID
P59665
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2KHT
Sequence
MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGS
RKNMACYCRIPACIAGERRYGTCIYQGRLWAFCC
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Sequence Length
94
Mass (Da)
10201
Sequence Removed Signal Peptide
DIPEVVVSLAWDESLAPKHPGSRKNMACYCRIPACIAGERRYGTCIYQGRLWAFCC
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Disulfide Bond
66-94;68-83;73-93
PDB ID
2KHT , 2PM1 , 3GNY , 3H6C , 3HJ2 , 3HJD , 3LO1 , 3LO2 , 3LO4 , 3LO6 , 3LO9 , 3LOE , 3LVX , 4DU0 , 4LB1 , 4LB7 , 4LBB , 4LBF
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv7.1 Inhibition rate
3 %
1 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate
6 %
1 μM
Blocker
 [1]
 Target Info    KCa3.1 Inhibition rate
7 %
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
7 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
102 nM
 .
Blocker
 [1]
References
Ref 1 Human -defensins are immune-related Kv1.3 channel inhibitors: new support for their roles in adaptive immunity. FASEB J. 2015 Oct;29(10):4324-33. doi: 10.1096/fj.15-274787. Epub 2015 Jul 6.
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