Peptide Information

General Information of This Peptide
Peptide ID
BTDP008614
Peptide Name
Potassium channel toxin kappa-KTx 2.2
Symonym
Toxin OmTx2
Species
Opisthacanthus madagascariensis (Scorpion)
Uniprot Name
KKX21_OPIMA
Alphafold ID
P0C1Z3
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1WQC
Sequence
DPCYEVCLQQHGNVKECEEACKHPVEY
   Click to Show/Hide
Sequence Length
27
Mass (Da)
3152
Sequence Removed Signal Peptide
DPCYEVCLQQHGNVKECEEACKHPVEY
   Click to Show/Hide
Disulfide Bond
3-21;7-17
PDB ID
1WQC , 1WQD
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Hemiscorpiidae
Genus: Opisthacanthus
Species: Opisthacanthus madagascariensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    potassium channels . . .
Blocker
 [1], [2]
 Target Info    Kv1 Inhibition rate
8 %
500 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
10 %
500 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
14 %
500 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate
17 %
500 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
24 %
500 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
36 %
500 μM
Blocker
 [1]
References
Ref 1 An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis. Biochem J. 2005 May 15;388(Pt 1):263-71. doi: 10.1042/BJ20041705.
Ref 2 Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new -KTX subfamily. Biochem Pharmacol. 2012 May 1;83(9):1307-17. doi: 10.1016/j.bcp.2012.01.021. Epub 2012 Jan 24.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.