Peptide Information

General Information of This Peptide
Peptide ID
BTDP008539
Peptide Name
Potassium channel toxin kappa-KTx 2.3
Symonym
Toxin OmTx3
Species
Opisthacanthus madagascariensis (Scorpion)
Uniprot Name
KKX23_OPIMA
Alphafold ID
P0C1Z4
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1WQE
Sequence
NDPCEEVCLQHTGNVKACEEACQ
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Sequence Length
23
Mass (Da)
2521
Sequence Removed Signal Peptide
NDPCEEVCLQHTGNVKACEEACQ
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Disulfide Bond
4-22;8-18
PDB ID
1WQE
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Hemiscorpiidae
Genus: Opisthacanthus
Species: Opisthacanthus madagascariensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate
8 %
500 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate
33 %
500 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
70 %
500 μM
Blocker
 [1]
References
Ref 1 An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis. Biochem J. 2005 May 15;388(Pt 1):263-71. doi: 10.1042/BJ20041705.
Ref 2 Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new -KTX subfamily. Biochem Pharmacol. 2012 May 1;83(9):1307-17. doi: 10.1016/j.bcp.2012.01.021. Epub 2012 Jan 24.
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