Peptide Information

General Information of This Peptide
Peptide ID
BTDP008513
Peptide Name
Potassium channel toxin alpha-KTx 6.3
Symonym
Neurotoxin HsTX1
Species
Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion)
Uniprot Name
KAX63_HETSP
Alphafold ID
P59867
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1QUZ
Sequence
ASCRTPKDCADPCRKETGCPYGKCMNRKCKCNRC
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Sequence Length
34
Mass (Da)
3828
Sequence Removed Signal Peptide
ASCRTPKDCADPCRKETGCPYGKCMNRKCKCNRC
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Disulfide Bond
3-24;9-29;13-31;19-34
PDB ID
1QUZ , 1WPD , 1Y2P
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Heterometrus
Species: Heterometrus spinifer
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
100 nM
Blocker
 [2]
 Target Info    Kv1.5 Inhibition rate .
100 nM
Blocker
 [2]
 Target Info    KCa2 Inhibition rate .
100 nM
Blocker
 [2]
 Target Info    KCa2 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    KCa1.1 Inhibition rate .
100 nM
Blocker
 [2]
 Target Info    Kv11 Inhibition rate
35 %
5 μM
Blocker
 [4]
 Target Info    Kv1 IC50
1 pM
 .
Blocker
 [1- 8]
 Target Info    Kv1.3 IC50
1129 pM
 .
Blocker
 [1- 8]
 Target Info    Kv1.3 IC50
0.012 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.1 IC50
7 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 IC50
625 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
711 nM
 .
Blocker
 [1- 8]
References
Ref 1 Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins. J Biol Chem. 2004 Dec 31;279(53):55690-6. doi: 10.1074/jbc.M410055200. Epub 2004 Oct 21.
Ref 2 The impact of the fourth disulfide bridge in scorpion toxins of the alpha-KTx6 subfamily. Proteins. 2005 Dec 1;61(4):1010-23. doi: 10.1002/prot.20681.
Ref 3 A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom. Biochem J. 1997 Nov 15;328 ( Pt 1)(Pt 1):321-7. doi: 10.1042/bj3280321.
Ref 4 A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18.
Ref 5 Free energy simulations of binding of HsTx1 toxin to Kv1 potassium channels: the basis of Kv1.3/Kv1.1 selectivity. J Phys Chem B. 2014 Jan 23;118(3):707-16. doi: 10.1021/jp410950h. Epub 2014 Jan 13.
Ref 6 A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases. Sci Rep. 2014 Mar 28;4:4509. doi: 10.1038/srep04509.
Ref 7 Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Clin Immunol. 2017 Jul;180:45-57. doi: 10.1016/j.clim.2017.03.014. Epub 2017 Apr 4.
Ref 8 Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: solution structure of the potassium channel inhibitor HsTX1. Protein Sci. 1999 Dec;8(12):2672-85. doi: 10.1110/ps.8.12.2672.
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