Peptide Information

General Information of This Peptide
Peptide ID
BTDP008504
Peptide Name
Potassium channel toxin alpha-KTx 4.6
Symonym
Tst26
Species
Tityus stigmurus (Brazilian scorpion)
Uniprot Name
KAX46_TITST
Alphafold ID
P0CB56
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0CB56
Sequence
VFINAKCRGSPECLPKCKQAIGKAAGKCMNGKCKCYP
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Sequence Length
37
Mass (Da)
3947
Sequence Removed Signal Peptide
VFINAKCRGSPECLPKCKQAIGKAAGKCMNGKCKCYP
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Disulfide Bond
7-28;13-33;17-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus stigmurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Dissociation constant
1.9 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
1.9 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
10.7 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
10.7 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    KCa1.1 Inhibition rate .
10 nM
Blocker
 [1]
References
Ref 1 Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus. Toxicon. 2009 Sep 15;54(4):379-89. doi: 10.1016/j.toxicon.2009.05.023. Epub 2009 Jun 3.
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