Peptide Information

General Information of This Peptide
Peptide ID
BTDP008491
Peptide Name
Potassium channel toxin alpha-KTx 24.1
Symonym
Potassium channel-blocking toxin 5
Species
Pandinus imperator (Emperor scorpion)
Uniprot Name
KA241_PANIM
Alphafold ID
C0HKB2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: C0HKB2
Sequence
VAKCSTSECGHACQQAGCRNSGCRYGSCICVGC
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Sequence Length
33
Mass (Da)
3343
Sequence Removed Signal Peptide
VAKCSTSECGHACQQAGCRNSGCRYGSCICVGC
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Disulfide Bond
4-23;9-28;13-30;18-33
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Pandinus
Species: Pandinus imperator
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
77 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
92 nM
 .
Blocker
 [1]
 Target Info    Shaker Dissociation constant
540 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Shab Inhibition rate .
1.5 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
100 nM
Blocker
 [1]
References
Ref 1 Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K(+)-channels. Toxicon. 2017 Jul;133:136-144. doi: 10.1016/j.toxicon.2017.05.011. Epub 2017 May 11.
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