Peptide Information

General Information of This Peptide
Peptide ID
BTDP008489
Peptide Name
Potassium channel toxin alpha-KTx 23.2
Symonym
Toxin Vm23; Toxin alpha-KTx 21.2
Species
Vaejovis mexicanus smithi (Mexican scorpion) (Vaejovis smithi)
Uniprot Name
KA232_VAEMS
Alphafold ID
P0DJ32
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DJ32
Sequence
AAAISCVGSKECLPKCKAQGCKSGKCMNKKCKCYC
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Sequence Length
35
Mass (Da)
3674
Sequence Removed Signal Peptide
AAAISCVGSKECLPKCKAQGCKSGKCMNKKCKCYC
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Disulfide Bond
6-26;12-31;16-33
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Vaejovidae
Genus: Vaejovis
Species: Vaejovis smithi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
2.9 pM
 . . [1]
 Target Info    KCa3.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate .
10 nM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
9.8 %
10 nM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
100 %
10 nM
Blocker
 [1]
References
Ref 1 Vm23 and vm24, two scorpion peptides that block human t-lymphocyte potassium channels (sub-type kv1.3) with high selectivity and decrease the in vivo dth-responses in rats.
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