Peptide Information

General Information of This Peptide
Peptide ID
BTDP008473
Peptide Name
Potassium channel toxin alpha-KTx 19.1
Symonym
BmK37; Neurotoxin BmBKTx1
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KA191_MESMA
Alphafold ID
P83407
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1Q2K
Sequence
AACYSSDCRVKCVAMGFSSGKCINSKCKCYK
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Sequence Length
31
Mass (Da)
3342
Sequence Removed Signal Peptide
AACYSSDCRVKCVAMGFSSGKCINSKCKCYK
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Disulfide Bond
3-22;8-27;12-29
PDB ID
1Q2K , 1R1G , 3E8Y
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    KCa1.1 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    KCa2 Inhibition rate
62 %
1 μM
Blocker
 [1]
References
Ref 1 BmBKTx1, a novel Ca2+-activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch. J Biol Chem. 2004 Aug 13;279(33):34562-9. doi: 10.1074/jbc.M312798200. Epub 2004 Jun 3.
Ref 2 Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch. Biochemistry. 2004 Apr 6;43(13):3764-71. doi: 10.1021/bi035412+.
Ref 3 Structure of the scorpion toxin BmBKTtx1 solved from single wavelength anomalous scattering of sulfur. J Struct Biol. 2004 Mar;145(3):289-94. doi: 10.1016/j.jsb.2003.11.012.
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