Peptide Information

General Information of This Peptide
Peptide ID
BTDP008453
Peptide Name
Potassium channel toxin alpha-KTx 10.1
Symonym
Cobatoxin-1; gtIX
Species
Centruroides noxius (Mexican scorpion)
Uniprot Name
KA101_CENNO
Alphafold ID
O46028
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1PJV
Sequence
MEGIAKITLILLFLFVTMHTFANWNTEAAVCVYRTCDKDCKRRGYRSGKCINNACKCYPY
GK
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Sequence Length
62
Mass (Da)
7131
Signal Sequence
MEGIAKITLILLFLFVTMHTFA
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Sequence Removed Signal Peptide
NWNTEAAVCVYRTCDKDCKRRGYRSGKCINNACKCYPYGK
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Disulfide Bond
31-50;36-55;40-57
PDB ID
1PJV
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides noxius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Dissociation constant
27 nM
 .
Blocker
 [1], [2]
 Target Info    KCa3.1 Dissociation constant
484 nM
 .
Blocker
 [2]
 Target Info    Shaker Dissociation constant
700 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
5.3 μM
 .
Blocker
 [2]
 Target Info    Kv1.1 Dissociation constant
24.4 μM
 .
Blocker
 [2]
 Target Info    Kv1 Inhibition constant
0.109 nM
 .
Blocker
 [1], [2]
 Target Info    KCa2 IC50
7.2 μM
 .
Blocker
 [1], [2]
References
Ref 1 Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a subfamily of potassium-channel-blocking scorpion toxins. Eur J Biochem. 1998 Jun 15;254(3):468-79. doi: 10.1046/j.1432-1327.1998.2540468.x.
Ref 2 Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels. Biochem J. 2004 Jan 1;377(Pt 1):37-49. doi: 10.1042/BJ20030977.
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