Peptide Information

General Information of This Peptide
Peptide ID
BTDP008429
Peptide Name
Mu-conotoxin PIIIA
Symonym
Mu-conotoxin P3.7
Species
Conus purpurascens (Purple cone)
Uniprot Name
CM3A_CONPU
Alphafold ID
P58925
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1R9I
Sequence
MSKLGVLLTICLLLFPITALPMDGDQPADRLAERMQDNISSEEHPFEKRQRLCCGFPKSC
RSRQCKPHRCCGR
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Sequence Length
73
Mass (Da)
8334
Signal Sequence
MSKLGVLLTICLLLFPITA
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Sequence Removed Signal Peptide
LPMDGDQPADRLAERMQDNISSEEHPFEKRQRLCCGFPKSCRSRQCKPHRCCGR
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Disulfide Bond
53-70;53-65;54-71;54-70;60-71;60-65
PDB ID
1R9I
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus purpurascens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
100 μM
 . [1- 9]
 Target Info    Kv1.2 Inhibition rate .
100 μM
 . [1- 9]
 Target Info    Kv1.3 Inhibition rate .
100 μM
 . [1- 9]
 Target Info    Kv1.5 Inhibition rate .
100 μM
 . [1- 9]
 Target Info    Kv2.1 Inhibition rate .
100 μM
 . [1- 9]
 Target Info    Kv1 Inhibition rate
73 %
100 μM
 . [1- 9]
 Target Info    Kv1.6 Inhibition rate
80 %
100 μM
 . [1- 9]
 Target Info    Nav1.4 IC50
36 - 41 nM
 . . [1- 9]
 Target Info    Nav1.6 IC50
100 nM
 . . [1- 9]
 Target Info    Nav1.1 IC50
120 nM
 . . [1- 9]
 Target Info    Nav1.2 IC50
620 nM
 . . [1- 9]
 Target Info    Nav1.7 IC50
>100 μM
 . . [1- 9]
 Target Info    Nav1.5 IC50
3.1 - 6.2 μM
 . . [1- 9]
 Target Info    Nav1.3 IC50
3.2 μM
 . . [1- 9]
References
Ref 1 Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms. Biochemistry. 2005 Jun 7;44(22):8176-86. doi: 10.1021/bi047541b.
Ref 2 mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes. J Neurosci. 1998 Jun 15;18(12):4473-81. doi: 10.1523/JNEUROSCI.18-12-04473.1998.
Ref 3 Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA. J Neurosci. 2000 Jan 1;20(1):76-80. doi: 10.1523/JNEUROSCI.20-01-00076.2000.
Ref 4 Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon. 2009 Jan;53(1):90-8. doi: 10.1016/j.toxicon.2008.10.017. Epub 2008 Nov 20.
Ref 5 A novel -conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. Br J Pharmacol. 2012 Jul;166(5):1654-68. doi: 10.1111/j.1476-5381.2012.01837.x.
Ref 6 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. doi: 10.1073/pnas.1107027108. Epub 2011 Jun 7.
Ref 7 Co-expression of Na(V) subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking -conotoxins. Br J Pharmacol. 2013 Apr;168(7):1597-610. doi: 10.1111/bph.12051.
Ref 8 Structurally diverse -conotoxin PIIIA isomers block sodium channel NaV 1.4. Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4058-61. doi: 10.1002/anie.201107011. Epub 2012 Mar 12.
Ref 9 Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. J Biol Chem. 2002 Jul 26;277(30):27247-55. doi: 10.1074/jbc.M201611200. Epub 2002 May 2.
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