Peptide Information

General Information of This Peptide
Peptide ID
BTDP008428
Peptide Name
Mu-conotoxin GIIIA
Symonym
G3.9; Geographutoxin I; Myotoxin I
Species
Conus geographus (Geography cone) (Nubecula geographus)
Uniprot Name
CM3A_CONGE
Alphafold ID
P01523
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1TCG
Sequence
MMSKLGVLLTICLLLFPLTALPMDGDEPANRPVERMQDNISSEQYPLFEKRRDCCTPPKK
CKDRQCKPQRCCAGR
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Sequence Length
75
Mass (Da)
8586
Signal Sequence
MMSKLGVLLTICLLLFPLTALP
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Sequence Removed Signal Peptide
MDGDEPANRPVERMQDNISSEQYPLFEKRRDCCTPPKKCKDRQCKPQRCCAGR
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Disulfide Bond
54-66;55-71;61-72
PDB ID
1TCG , 1TCH , 1TCJ , 1TCK
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus geographus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
100 μM
 . [1- 13]
 Target Info    Kv1.2 Inhibition rate .
100 μM
 . [1- 13]
 Target Info    Kv1.3 Inhibition rate .
100 μM
 . [1- 13]
 Target Info    Kv1.5 Inhibition rate .
100 μM
 . [1- 13]
 Target Info    Kv1.6 Inhibition rate .
100 μM
 . [1- 13]
 Target Info    Kv1 Inhibition rate .
100 μM
 . [1- 13]
 Target Info    Kv2.1 Inhibition rate .
100 μM
 . [1- 13]
 Target Info    Nav1.4 IC50
19 - 110 nM
 . . [1- 15]
 Target Info    Nav1.1 IC50
260 nM
 . . [1- 15]
 Target Info    Nav1.6 IC50
680 nM
 . . [1- 15]
 Target Info    Nav1.2 IC50
2.7 - 17.8 μM
 . . [1- 15]
References
Ref 1 Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nat Commun. 2014 Mar 24;5:3521. doi: 10.1038/ncomms4521.
Ref 2 Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms. Biochemistry. 2005 Jun 7;44(22):8176-86. doi: 10.1021/bi047541b.
Ref 3 The amino acid sequences of homologous hydroxyproline-containing myotoxins from the marine snail Conus geographus venom. FEBS Lett. 1983 May 8;155(2):277-80. doi: 10.1016/0014-5793(82)80620-0.
Ref 4 Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus. FEBS Lett. 1990 May 7;264(1):29-32. doi: 10.1016/0014-5793(90)80756-9.
Ref 5 Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates. Biochemistry. 1992 Sep 8;31(35):8229-38. doi: 10.1021/bi00150a016.
Ref 6 Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA. J Neurosci. 2000 Jan 1;20(1):76-80. doi: 10.1523/JNEUROSCI.20-01-00076.2000.
Ref 7 Role of hydroxyprolines in the in vitro oxidative folding and biological activity of conotoxins. Biochemistry. 2008 Feb 12;47(6):1741-51. doi: 10.1021/bi701934m. Epub 2008 Jan 12.
Ref 8 Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon. 2009 Jan;53(1):90-8. doi: 10.1016/j.toxicon.2008.10.017. Epub 2008 Nov 20.
Ref 9 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. doi: 10.1073/pnas.1107027108. Epub 2011 Jun 7.
Ref 10 NMR Structure of -Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na(V) Channel Potency. Molecules. 2018 Oct 22;23(10):2715. doi: 10.3390/molecules23102715.
Ref 11 Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations. FEBS Lett. 1991 Jan 28;278(2):160-6. doi: 10.1016/0014-5793(91)80107-e.
Ref 12 Tertiary structure of conotoxin GIIIA in aqueous solution. Biochemistry. 1991 Jul 16;30(28):6908-16. doi: 10.1021/bi00242a014.
Ref 13 Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations. Biochemistry. 1992 Dec 22;31(50):12577-84. doi: 10.1021/bi00165a006.
Ref 14 Conus geographus toxins that discriminate between neuronal and muscle sodium channels. J Biol Chem. 1985 Aug 5;260(16):9280-8.
Ref 15 Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels. J Biol Chem. 1991 Sep 15;266(26):16989-91.
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