Peptide Information

General Information of This Peptide
Peptide ID
BTDP008427
Peptide Name
Mesomartoxin
Symonym
MMTX
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KA26U_MESMA
Alphafold ID
P0DL65
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2RTZ
Sequence
MMSRLSVFILIALVLSVIIDVLNNSKVEGACVENCRKYCQDKGARNGKCINSNCHCYY
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Sequence Length
58
Mass (Da)
6502
Signal Sequence
MMSRLSVFILIALVLSVIIDVLNNSKVEG
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Sequence Removed Signal Peptide
ACVENCRKYCQDKGARNGKCINSNCHCYY
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Disulfide Bond
31-49;35-54;39-56
PDB ID
2RTZ
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1 Inhibition rate .
50 μM
Blocker
 [1]
 Target Info    Shaker-IR IC50
0.054 nM
 .
Blocker
 [1]
 Target Info    Shaker-IR IC50
0.054 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
15.6 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
15.6 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
12.5 μM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
12.5 μM
 .
Blocker
 [1]
References
Ref 1 Mesomartoxin, a new K(v)1.2-selective scorpion toxin interacting with the channel selectivity filter. Biochem Pharmacol. 2015 Jan 15;93(2):232-9. doi: 10.1016/j.bcp.2014.12.002. Epub 2014 Dec 13.
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