Peptide Information

General Information of This Peptide
Peptide ID
BTDP008372
Peptide Name
Jingzhaotoxin F7-15.33
Symonym
Peptide F7-15.33
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
NTA_CHIGU
Alphafold ID
P0CH55
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0CH55
Sequence
LCSREGEFCYKLRKCCAGFYCKAFVLHCYRN
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Sequence Length
31
Mass (Da)
3712
Sequence Removed Signal Peptide
LCSREGEFCYKLRKCCAGFYCKAFVLHCYRN
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Disulfide Bond
2-16;9-21;15-28
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate .
100 μM
Blocker
 [2]
 Target Info    Kv1.1 Inhibition rate .
100 μM
Blocker
 [2]
 Target Info    Kv1.3 Inhibition rate .
100 μM
Blocker
 [2]
 Target Info    Kv2.1 Inhibition rate .
100 μM
Blocker
 [2]
 Target Info    Kv4.2 IC50
68 nM
 .
Blocker
 [1]
 Target Info    Kv4.3 IC50
210 nM
 .
Blocker
 [1]
References
Ref 1 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 2 Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao. J Venom Anim Toxins Incl Trop Dis. 2020 May 29;26:e20190043. doi: 10.1590/1678-9199-JVATITD-2019-0043.
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