General Information of This Target
Target ID
BTDT00071
Target Name
Potassium voltage-gated channel subfamily A member 2 (kcna2)
Target Bioclass
Transporter and channel
Uniprot ID
P22739
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
?
Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
kcna2
Synonym
Voltage-gated potassium channel subunit Kv1.2; xSHA2
Sequence
MTVATGDLTDGSVGFAGHPQDSYDPEPDHECCERVVINISGLRFETQLKTLSQFPETLLG
DPKKRMRYFDPLRNEYFFDRNRPSFDAILYFYQSGGRLRRPVNVPLDIFSEEIRFYELGE
EAMEIFREDEGFIKEEERPLPDNEFQKQVWLLFEYPESSGPARIIAIISVTVILISIVSF
CLETLPVFRDENEDMHGSGGNYYSYPNSTVRFQKSNTFTDPFFIVETLCIIWFSFEFLVR
FLACPSKAVFFTNLMNIIDIVAIIPYFITLGTELAEKTEDGQQGQQAMSLAILRVIRLVR
VFRIFKLSRHSKGLQILGQTLNASMRELGLLIFFLFIGVILFSSAVFFAEADERDSQFPS
IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE
TEGEEQAQYLQVTSCPKIPSSPDLQKSRSASTLSKSDYMEIQEGVNHSNEDFREKNLKTA
NCTLGNTNYVNITKMLTDV

    Click to Show/Hide
Family
the potassium channel family
Function
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and central nervous system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels with other family members; the channels characteristics depend critically on the types of channel-forming alpha subunits that are present. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure. Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials. KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing. Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination. Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus.

    Click to Show/Hide
Taxonomy ID
8355
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Amphibia
Order: Anura
Family: Pipidae
Genus: Xenopus
Species: Xenopus laevis
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Conopeptide Y-Pl1 IC50
2 μM
[1]
References
Ref 1 Tyrosine-rich conopeptides affect voltage-gated K+ channels. J Biol Chem. 2008 Aug 22;283(34):23026-32. doi: 10.1074/jbc.M800084200. Epub 2008 May 27.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.