Target Information

General Information of This Target
Target ID
BTDT00002
Target Name
BTB domain-containing protein (kcna6.L)
Target Bioclass
Transporter and channel
Uniprot ID
A0A974HS24
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
kcna6.L
Gene ID
108710774
Sequence
MTVVSGDNVDETLVSLGALGQEGYDADRANQDCCERVVINISGLRFETQLRTLSQFPKTL
LGDPRKRMRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPVDIFLEEIKFYEL
GQEVIEIFRDDEGFIKEEERPLPENDFQKQVWLLFEYPESSGPARGIAIVSVLIILISIV
IFCLETLPEFREEARQASGQTAVNGTRTFSNSPFTDPFFLTETLCIIWFSFELLVRFFAC
PSKPAFFKNMMNVIDIVAIIPYFITLGTELAEQQGSNGQQAMSLAILRVIRLVRVFRIFK
LSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAETDDPESLFTSIPDAFW
WAVVSMTTVGYGDMYPMTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQ
SQYTHVTCGQQPSSYGELKKSESKQSFNRSDFMESEELDDMRYGHYTANQHYAEPKKLTD
V

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Taxonomy ID
8355
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Kingdom: Metazoa
Phylum: Chordata
Class: Amphibia
Order: Anura
Family: Pipidae
Genus: Xenopus
Species: Xenopus laevis
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Conopeptide Y-Pl1 IC50
170 nM
 [1]
 Toxin Info    Conopeptide Y-Fe1 IC50
8.8 μM
 [1]
References
Ref 1 Tyrosine-rich conopeptides affect voltage-gated K+ channels. J Biol Chem. 2008 Aug 22;283(34):23026-32. doi: 10.1074/jbc.M800084200. Epub 2008 May 27.
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