Peptide Information

General Information of This Peptide
Peptide ID
BTDP008349
Peptide Name
Beta/kappa-theraphotoxin-Gi1a
Symonym
GiTx1
Species
Grammostola iheringi (Argentinean black tarantula) (Eurypelma iheringii)
Uniprot Name
TX1A_GRAIH
Alphafold ID
C0HJJ7
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: C0HJJ7
Sequence
SCQKWMWTCDQKRPCCEDMVCKLWCKIIK
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Sequence Length
29
Mass (Da)
3594
Sequence Removed Signal Peptide
SCQKWMWTCDQKRPCCEDMVCKLWCKIIK
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Disulfide Bond
2-16;9-21;15-25
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Grammostola
Species: Grammostola iheringi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker-IR Inhibition rate .
2 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
2 μM
Blocker
 [1]
 Target Info    Kv4.3 Inhibition rate
95 %
2 μM
Blocker
 [1]
 Target Info    VdNav IC50
124.05 nM
 .
Blocker
 [1]
 Target Info    Nav1.6 IC50
156.39 nM
 .
Blocker
 [1]
 Target Info    Kv11 IC50
3.695 μM
 .
Blocker
 [1]
 Target Info    Kv11.1 IC50
3.7 μM
 .
Blocker
 [1]
References
Ref 1 GiTx1(/-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels. Biochimie. 2020 Sep;176:138-149. doi: 10.1016/j.biochi.2020.07.008. Epub 2020 Jul 24.
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