Peptide Information

General Information of This Peptide
Peptide ID
BTDP004023
Peptide Name
Peptide TsPep3
Symonym
Tityustoxin-13
Species
Tityus serrulatus (Brazilian scorpion)
Uniprot Name
KEX1S_TITSE
Alphafold ID
P0C176
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0C176
Sequence
MKLSCGFLLIFLVLSAMIATFSEVEATVKCGGCNRKCCPGGCRSGKCINGKCQCYGRSDL
NEEFENYQ
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Sequence Length
68
Mass (Da)
7427
Signal Sequence
MKLSCGFLLIFLVLSAMIATFSEVEA
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Sequence Removed Signal Peptide
TVKCGGCNRKCCPGGCRSGKCINGKCQCYGRSDLNEEFENYQ
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Disulfide Bond
30-38;33-54;37-47;42-52
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus serrulatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate
5 %
3 μM
 . [1], [2], [3]
 Target Info    Kv1.3 Inhibition rate
10 %
3 μM
 . [1], [2], [3]
 Target Info    Kv1.4 Inhibition rate
20 %
3 μM
 . [1], [2], [3]
 Target Info    Kv11/ERG Inhibition rate
24 %
3 μM
 . [1], [2], [3]
 Target Info    Shaker-IR Inhibition rate
27 %
3 μM
 . [1], [2], [3]
References
Ref 1 Novel components of Tityus serrulatus venom: A transcriptomic approach. Toxicon. 2021 Jan 15;189:91-104. doi: 10.1016/j.toxicon.2020.11.001. Epub 2020 Nov 10.
Ref 2 Novel structural class of four disulfide-bridged peptides from Tityus serrulatus venom. Biochem Biophys Res Commun. 2003 Feb 21;301(4):1086-92. doi: 10.1016/s0006-291x(03)00082-2.
Ref 3 Tityus serrulatus scorpion venom and toxins: an overview. Protein Pept Lett. 2009;16(8):920-32. doi: 10.2174/092986609788923329.
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