Peptide Information

General Information of This Peptide
Peptide ID
BTDP000355
Peptide Name
Potassium channel toxin Bgk (T33A)
Symonym
Potassium channel toxin Bgk (T33A)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
VCRDWFKETACRHAKSLGNCRTSQKYRANCAKTCELC
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Mutant Sequence
VCRDWFKETACRHAKSLGNCRTSQKYRANCAKACELC
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Sequence Length
37
Mass(Da)
4246
Sequence Removed Signal Peptide
VCRDWFKETACRHAKSLGNCRTSQKYRANCAKACELC
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate
46 %
2 nM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
65 %
50 nM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate
66 %
50 nM
Blocker
 [1]
 Target Info    Kv1 IC50
70 nM
 .
Blocker
 [2]
References
Ref 1 Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity. J Biol Chem. 1999 Dec 10;274(50):35653-61. doi: 10.1074/jbc.274.50.35653.
Ref 2 On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. J Biol Chem. 1997 Feb 14;272(7):4302-9. doi: 10.1074/jbc.272.7.4302.
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