Peptide Information

General Information of This Peptide

Peptide ID	BTDP000353
Peptide Name	Potassium channel toxin Bgk (S23A)
Symonym	Potassium channel toxin Bgk (S23A)
3D Structure	Download 2D Sequence Download FASTA 3D Structure Download PDB Source Predict by Alphafold2 ? Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence	VCRDWFKETACRHAKSLGNCRTSQKYRANCAKTCELC Click to Show/Hide
Mutant Sequence	VCRDWFKETACRHAKSLGNCRTAQKYRANCAKTCELC Click to Show/Hide
Sequence Length	37
Mass(Da)	4260
Sequence Removed Signal Peptide	VCRDWFKETACRHAKSLGNCRTAQKYRANCAKTCELC Click to Show/Hide
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N.A.

Full List of Activity Data of This Peptide Toxin

Target Name	Activity Data Type	Activity Data	Concentration	Note	Reference
Target Info Kv1.1	Dissociation constant	920 nM	.	Blocker	[1]
Target Info Kv1.3	Inhibition rate	10 %	50 nM	Blocker	[2]
Target Info Kv1.2	Inhibition rate	17 %	2 nM	Blocker	[2]
Target Info Kv1.1	Inhibition rate	23 %	50 nM	Blocker	[2]
Target Info Kv1	IC50	30 nM	.	Blocker	[3]

References

Ref 1	Structure of the BgK-Kv1.1 complex based on distance restraints identified by double mutant cycles. Molecular basis for convergent evolution of Kv1 channel blockers. J Biol Chem. 2002 Oct 4;277(40):37406-13. doi: 10.1074/jbc.M206205200. Epub 2002 Jul 19.
Ref 2	Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity. J Biol Chem. 1999 Dec 10;274(50):35653-61. doi: 10.1074/jbc.274.50.35653.
Ref 3	On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. J Biol Chem. 1997 Feb 14;272(7):4302-9. doi: 10.1074/jbc.272.7.4302.

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