Target Information

General Information of This Target
Target ID
BTDT10310
Target Name
Voltage-gated sodium channel
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Conotoxin phi-MiXXVIIB Effect . [1]
 Toxin Info    Conotoxin Lo6/7a Effect . [2]
 Toxin Info    Conotoxin Lo6/7b Effect . [2]
 Toxin Info    Conotoxin AusB Effect . [2]
 Toxin Info    Delta-actitoxin-Avd2c Inhibition rate
100 %
 [3], [4]
 Toxin Info    Sodium channel neurotoxin BmK NT2 Effective concentration 50
0.91 μM
 [5]
 Toxin Info    Mu-theraphotoxin-Cg2a 2 Effective concentration 50
1.77 μM
 [6], [7], [8]
 Toxin Info    Mu-theraphotoxin-Cg2a 1 Effective concentration 50
1.77 μM
 [6], [7], [8]
References
Ref 1 Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Mol Cell Proteomics. 2013 Dec;12(12):3824-33. doi: 10.1074/mcp.M113.030353. Epub 2013 Sep 16.
Ref 2 Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs. 2016 Oct 27;14(11):199. doi: 10.3390/md14110199.
Ref 3 Fusion and retrotransposition events in the evolution of the sea anemone Anemonia viridis neurotoxin genes. J Mol Evol. 2009 Aug;69(2):115-24. doi: 10.1007/s00239-009-9258-x. Epub 2009 Jul 16.
Ref 4 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
Ref 5 Activation of sodium channel by a novel -scorpion toxin, BmK NT2, stimulates ERK1/2 and CERB phosphorylation through a Ca(2+) dependent pathway in neocortical neurons. Int J Biol Macromol. 2017 Nov;104(Pt A):70-77. doi: 10.1016/j.ijbiomac.2017.05.163. Epub 2017 Jun 4.
Ref 6 JZTX-IV, a unique acidic sodium channel toxin isolated from the spider Chilobrachys jingzhao. Toxicon. 2008 Dec 15;52(8):871-80. doi: 10.1016/j.toxicon.2008.08.018. Epub 2008 Sep 24.
Ref 7 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 8 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
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