Peptide Information

General Information of This Peptide
Peptide ID
BTDP002092
Peptide Name
Mu-theraphotoxin-Cg2a 2
Symonym
Jingzhaotoxin-31.2; Jingzhaotoxin-IV; Peptide F1-23.73
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZ31B_CHIGU
Alphafold ID
B1P1F3
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: B1P1F3
Sequence
MKVSVVITLAVLGVMFVWASAAELEERGSDQRDSPAWIKSMERIFQSEERECTKFLGGCS
EDSECCPHLGCKDVLYYCAWDGTFGK
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Sequence Length
86
Mass (Da)
9633
Signal Sequence
MKVSVVITLAVLGVMFVWASA
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Sequence Removed Signal Peptide
AELEERGSDQRDSPAWIKSMERIFQSEERECTKFLGGCSEDSECCPHLGCKDVLYYCAWD
GTFGK
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Disulfide Bond
52-66;59-71;65-78
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav Effective concentration 50
1.77 μM
 .
DRG neurons
 [1], [2], [3]
References
Ref 1 JZTX-IV, a unique acidic sodium channel toxin isolated from the spider Chilobrachys jingzhao. Toxicon. 2008 Dec 15;52(8):871-80. doi: 10.1016/j.toxicon.2008.08.018. Epub 2008 Sep 24.
Ref 2 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 3 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
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