Peptide Information

General Information of This Peptide
Peptide ID
BTDP005660
Peptide Name
Sodium channel neurotoxin BmK NT2
Symonym
Alpha-scorpion toxin
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
SCXT2_MESMA
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
VRDAYIAKPENCVYHCAGNEGCNNLCTCNGAT
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Sequence Length
32
Mass (Da)
3405
Sequence Removed Signal Peptide
VRDAYIAKPENCVYHCAGNEGCNNLCTCNGAT
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Disulfide Bond
12-?;16-?;22-?;26-?;28-?
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav Effective concentration 50
0.91 μM
 . . [1]
References
Ref 1 Activation of sodium channel by a novel -scorpion toxin, BmK NT2, stimulates ERK1/2 and CERB phosphorylation through a Ca(2+) dependent pathway in neocortical neurons. Int J Biol Macromol. 2017 Nov;104(Pt A):70-77. doi: 10.1016/j.ijbiomac.2017.05.163. Epub 2017 Jun 4.
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