Target Information

General Information of This Target
Target ID
BTDT10287
Target Name
Transient receptor potential cation channel subfamily V member 1
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    TauPI-stichotoxin-Hcr2b IC50
54 nM
 [1- 5]
 Toxin Info    PI-stichotoxin-Hcr2h IC50
6.9 μM
 [6], [7], [8]
References
Ref 1 Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1). J Biol Chem. 2008 Aug 29;283(35):23914-21. doi: 10.1074/jbc.M800776200. Epub 2008 Jun 25.
Ref 2 [Interaction of sea amemone Heteractis crispa Kunitz type polypeptides with pain vanilloid receptor TRPV1: in silico investigation]. Bioorg Khim. 2012 Mar-Apr;38(2):185-98. doi: 10.1134/s106816201202015x.
Ref 3 Modulation of TRPV1-dependent contractility of normal and diabetic bladder smooth muscle by analgesic toxins from sea anemone Heteractis crispa. Life Sci. 2012 Nov 2;91(19-20):912-20. doi: 10.1016/j.lfs.2012.09.001. Epub 2012 Sep 12.
Ref 4 Polypeptide modulators of TRPV1 produce analgesia without hyperthermia. Mar Drugs. 2013 Dec 16;11(12):5100-15. doi: 10.3390/md11125100.
Ref 5 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
Ref 6 Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor. Mar Drugs. 2016 Dec 15;14(12):229. doi: 10.3390/md14120229.
Ref 7 Kunitz-Type Peptides from the Sea Anemone Heteractis crispa Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities. Biomedicines. 2020 Nov 4;8(11):473. doi: 10.3390/biomedicines8110473.
Ref 8 Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model. Biomedicines. 2021 Mar 10;9(3):283. doi: 10.3390/biomedicines9030283.
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