Peptide Information

General Information of This Peptide
Peptide ID
BTDP008442
Peptide Name
PI-stichotoxin-Hcr2h
Symonym
Kunitz-type serine protease inhibitor HCRG21
Species
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Uniprot Name
VKT2H_HETCR
Alphafold ID
P0DL86
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DL86
Sequence
RGICSEPKVVGPCTAYFRRFYFDSETGKCTPFIYGGCEGNGNNFETLRACRAICRA
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Sequence Length
56
Mass (Da)
6234
Sequence Removed Signal Peptide
RGICSEPKVVGPCTAYFRRFYFDSETGKCTPFIYGGCEGNGNNFETLRACRAICRA
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Disulfide Bond
4-54;13-37;29-50
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Radianthus
Species: Radianthus crispa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    potassium channels . . .
Blocker
 [1], [2], [3]
 Target Info    trypsin Inhibition constant
0.2 μM
 .
Blocker
 [1], [2], [3]
 Target Info    chymotrypsin Inhibition constant
0.7 μM
 .
Blocker
 [1], [2], [3]
 Target Info    TRPV1 IC50
6.9 μM
 .
Blocker
 [1], [2], [3]
References
Ref 1 Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor. Mar Drugs. 2016 Dec 15;14(12):229. doi: 10.3390/md14120229.
Ref 2 Kunitz-Type Peptides from the Sea Anemone Heteractis crispa Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities. Biomedicines. 2020 Nov 4;8(11):473. doi: 10.3390/biomedicines8110473.
Ref 3 Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model. Biomedicines. 2021 Mar 10;9(3):283. doi: 10.3390/biomedicines9030283.
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