Peptide Information

General Information of This Peptide
Peptide ID
BTDP002142
Peptide Name
TauPI-stichotoxin-Hcr2b
Symonym
Analgesic polypeptide HC1
Species
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Uniprot Name
VKT2B_HETCR
Alphafold ID
B2G331
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: B2G331
Sequence
MKGTFLICLILIAGFSFKSTQAGSICLEPKVVGPCTAYFRRFYFDSETGKCTVFIYGGCE
GNGNNFETLRACRAICRA
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Sequence Length
78
Mass (Da)
8565
Signal Sequence
MKGTFLICLILIAGFSFKSTQA
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Sequence Removed Signal Peptide
GSICLEPKVVGPCTAYFRRFYFDSETGKCTVFIYGGCEGNGNNFETLRACRAICRA
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Disulfide Bond
26-76;35-59;51-72
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Radianthus
Species: Radianthus crispa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Inhibition constant
1 μM
 .
Capsaicin-induced response
 [1- 5]
 Target Info    chymotrypsin Inhibition constant
5 μM
 .
Capsaicin-induced response
 [1- 5]
 Target Info    TRPV1 IC50
54 nM
 .
Capsaicin-induced response
 [1- 5]
References
Ref 1 Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1). J Biol Chem. 2008 Aug 29;283(35):23914-21. doi: 10.1074/jbc.M800776200. Epub 2008 Jun 25.
Ref 2 [Interaction of sea amemone Heteractis crispa Kunitz type polypeptides with pain vanilloid receptor TRPV1: in silico investigation]. Bioorg Khim. 2012 Mar-Apr;38(2):185-98. doi: 10.1134/s106816201202015x.
Ref 3 Modulation of TRPV1-dependent contractility of normal and diabetic bladder smooth muscle by analgesic toxins from sea anemone Heteractis crispa. Life Sci. 2012 Nov 2;91(19-20):912-20. doi: 10.1016/j.lfs.2012.09.001. Epub 2012 Sep 12.
Ref 4 Polypeptide modulators of TRPV1 produce analgesia without hyperthermia. Mar Drugs. 2013 Dec 16;11(12):5100-15. doi: 10.3390/md11125100.
Ref 5 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
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