Target Information

General Information of This Target
Target ID
BTDT10249
Target Name
ShakerB
Target Bioclass
Transporter and channel
Taxonomy ID
7227
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Diptera
Family: Drosophilidae
Genus: Drosophila
Species: Drosophila melanogaster
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    MTX (G33A) IC50
0.8 nM
 [1]
 Toxin Info    MTX (P12A) IC50
1.1 nM
 [2]
 Toxin Info    MTXG18G[Abu],G33G[Abu]) IC50
1.2 nM
 [3]
 Toxin Info    MTX (P20A) IC50
1.4 nM
 [2]
 Toxin Info    MTX (K15Q) IC50
2.3 nM
 [1]
 Toxin Info    MTX (S2V,C3I,T4G,G5Q,S6R,K7C,D8T,C9G,Y10S,A11K,P12D,R14Y,K15A,Q16P,T17C,G18R,C19K,P20Q,N21T,A22G,K23C,C24P,I25N,N26A,S28C,C29I,K30N,C31K,Y32S,G33C,C34K) IC50
53.2 nM
 [4]
 Toxin Info    MTX (P12A,P20A) IC50
130 nM
 [2]
 Toxin Info    MTX (A23K) IC50
1.997 μM
 [5]
References
Ref 1 Maurotoxin versus Pi1/HsTx1 scorpion toxins. Toward new insights in the understanding of their distinct disulfide bridge patterns. J Biol Chem. 2000 Dec 15;275(50):39394-402. doi: 10.1074/jbc.M006810200.
Ref 2 Disulfide bridge reorganization induced by proline mutations in maurotoxin. FEBS Lett. 2001 Feb 2;489(2-3):202-7. doi: 10.1016/s0014-5793(00)02433-9.
Ref 3 Synthesis, 1H NMR structure, and activity of a three-disulfide-bridged maurotoxin analog designed to restore the consensus motif of scorpion toxins. J Biol Chem. 2000 May 5;275(18):13605-12. doi: 10.1074/jbc.275.18.13605.
Ref 4 Synthesis, 3-D structure, and pharmacology of a reticulated chimeric peptide derived from maurotoxin and Tsk scorpion toxins. Biochem Biophys Res Commun. 2002 Mar 1;291(3):640-8. doi: 10.1006/bbrc.2002.6496.
Ref 5 Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K+ channels. J Pept Res. 2000 Jun;55(6):419-27. doi: 10.1034/j.1399-3011.2000.00715.x.
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