Peptide Information

General Information of This Peptide
Peptide ID
BTDP008932
Peptide Name
MTX (S2V,C3I,T4G,G5Q,S6R,K7C,D8T,C9G,Y10S,A11K,P12D,R14Y,K15A,Q16P,T17C,G18R,C19K,P20Q,N21T,A22G,K23C,C24P,I25N,N26A,S28C,C29I,K30N,C31K,Y32S,G33C,C34K)
Symonym
MTX (S2V,C3I,T4G,G5Q,S6R,K7C,D8T,C9G,Y10S,A11K,P12D,R14Y,K15A,Q16P,T17C,G18R,C19K,P20Q,N21T,A22G,K23C,C24P,I25N,N26A,S28C,C29I,K30N,C31K,Y32S,G33C,C34K)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
VSCTGSKDCYAPCRKQTGCPNAKCINKSCKCYGC
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Mutant Sequence
VVIGQRCTGSKDCYAPCRKQTGCPNAKCINKSCKCYGC
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Sequence Length
38
Mass(Da)
4079
Sequence Removed Signal Peptide
VVIGQRCTGSKDCYAPCRKQTGCPNAKCINKSCKCYGC
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    ShakerB IC50
53.2 nM
 .
Blocker
 [1]
References
Ref 1 Synthesis, 3-D structure, and pharmacology of a reticulated chimeric peptide derived from maurotoxin and Tsk scorpion toxins. Biochem Biophys Res Commun. 2002 Mar 1;291(3):640-8. doi: 10.1006/bbrc.2002.6496.
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