Peptide Information

General Information of This Peptide
Peptide ID
BTDP001069
Peptide Name
MTX (G33A)
Symonym
MTX (G33A)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
VSCTGSKDCYAPCRKQTGCPNAKCINKSCKCYGC
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Mutant Sequence
VSCTGSKDCYAPCRKQTGCPNAKCINKSCKCYAC
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Sequence Length
34
Mass(Da)
3626
Sequence Removed Signal Peptide
VSCTGSKDCYAPCRKQTGCPNAKCINKSCKCYAC
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    KCa2.1 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    KCa2.2 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    KCa2.3 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv1.2 IC50
0.142 nM
 .
Blocker
 [1]
 Target Info    ShakerB IC50
0.8 nM
 .
Blocker
 [1]
 Target Info    KCa2 IC50
395 nM
 .
Blocker
 [1]
References
Ref 1 Maurotoxin versus Pi1/HsTx1 scorpion toxins. Toward new insights in the understanding of their distinct disulfide bridge patterns. J Biol Chem. 2000 Dec 15;275(50):39394-402. doi: 10.1074/jbc.M006810200.
Ref 2 Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels. Mol Pharmacol. 2003 Feb;63(2):409-18. doi: 10.1124/mol.63.2.409.
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