Target Information

General Information of This Target
Target ID
BTDT10168
Target Name
Nicotinic acetylcholine receptor alpha-7-similar
Target Bioclass
Receptor
Taxonomy ID
6523
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Family: Lymnaeidae
Genus: Lymnaea
Species: Lymnaea stagnalis
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Acidic phospholipase A2 CM-II IC50
37 nM
 [1], [2], [3], [4]
 Toxin Info    Acidic phospholipase A2 Vur-PL2B IC50
>30 μM
 [5], [4]
 Toxin Info    Basic phospholipase A2 vurtoxin IC50
10.5 μM
 [5], [4]
References
Ref 1 Regional and accelerated molecular evolution in group I snake venom gland phospholipase A2 isozymes. Toxicon. 2000 Mar;38(3):449-62. doi: 10.1016/s0041-0101(99)00165-8.
Ref 2 Purification, some properties and amino-acid sequences of two phospholipases A (CM-II and CM-III) from Naja naja kaouthia venom. Eur J Biochem. 1980 Dec;112(3):493-9. doi: 10.1111/j.1432-1033.1980.tb06112.x.
Ref 3 A new type of thrombin inhibitor, noncytotoxic phospholipase A2, from the Naja haje cobra venom. Toxicon. 2010 Feb-Mar;55(2-3):186-94. doi: 10.1016/j.toxicon.2009.07.011. Epub 2009 Jul 19.
Ref 4 Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2. PLoS One. 2014 Dec 18;9(12):e115428. doi: 10.1371/journal.pone.0115428. eCollection 2014.
Ref 5 cDNA cloning, structural, and functional analyses of venom phospholipases A? and a Kunitz-type protease inhibitor from steppe viper Vipera ursinii renardi. Toxicon. 2011 Feb;57(2):332-41. doi: 10.1016/j.toxicon.2010.12.012. Epub 2010 Dec 23.
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