Peptide Information

General Information of This Peptide
Peptide ID
BTDP003816
Peptide Name
Acidic phospholipase A2 CM-II
Symonym
Acidic phospholipase A2 1; NnkPLA-I; Phosphatidylcholine 2-acylhydrolase
Species
Naja kaouthia (Monocled cobra) (Naja siamensis)
Uniprot Name
PA2A1_NAJKA
Alphafold ID
P00596
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P00596
Sequence
MNPAHLLILAAVCVSPLGAFSNRPMPLNLYQFKNMIQCTVPNRSWWDFADYGCYCGRGGS
GTPVDDLDRCCQVHDNCYNEAEKISRCWPYFKTYSYECSQGTLTCKGDNDACAAAVCDCD
RLAAICFAGAPYNNNNYNIDLKARCQ
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Sequence Length
146
Mass (Da)
16271
Signal Sequence
MNPAHLLILAAVCVSPLGAFS
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Sequence Removed Signal Peptide
NRPMPLNLYQFKNMIQCTVPNRSWWDFADYGCYCGRGGSGTPVDDLDRCCQVHDNCYNEA
EKISRCWPYFKTYSYECSQGTLTCKGDNDACAAAVCDCDRLAAICFAGAPYNNNNYNIDL
KARCQ
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Disulfide Bond
38-98;53-145;55-71;70-126;77-119;87-112;105-117
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Naja
Species: Naja kaouthia
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-7-similar IC50
37 nM
 .
Suppress the acetylcholine (ACh)-evoked current
 [1], [2], [3], [4]
 Target Info    acetylcholine binding protein (AChBP) IC50
>100 μM
 . . [1], [2], [3], [4]
 Target Info    lymnaea stagnalis acetylcholine-binding protein (Ls-AChBP) IC50
1 μM
 . . [1], [2], [3], [4]
 Target Info    nAChR IC50
1.2 μM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-7 IC50
3.2 μM
 . . [1], [2], [3], [4]
References
Ref 1 Regional and accelerated molecular evolution in group I snake venom gland phospholipase A2 isozymes. Toxicon. 2000 Mar;38(3):449-62. doi: 10.1016/s0041-0101(99)00165-8.
Ref 2 Purification, some properties and amino-acid sequences of two phospholipases A (CM-II and CM-III) from Naja naja kaouthia venom. Eur J Biochem. 1980 Dec;112(3):493-9. doi: 10.1111/j.1432-1033.1980.tb06112.x.
Ref 3 A new type of thrombin inhibitor, noncytotoxic phospholipase A2, from the Naja haje cobra venom. Toxicon. 2010 Feb-Mar;55(2-3):186-94. doi: 10.1016/j.toxicon.2009.07.011. Epub 2009 Jul 19.
Ref 4 Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2. PLoS One. 2014 Dec 18;9(12):e115428. doi: 10.1371/journal.pone.0115428. eCollection 2014.
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