Peptide Information

General Information of This Peptide
Peptide ID
BTDP003583
Peptide Name
Acidic phospholipase A2 Vur-PL2B
Symonym
Phosphatidylcholine 2-acylhydrolase
Species
Vipera renardi (Steppe viper) (Vipera ursinii renardi)
Uniprot Name
PA2A2_VIPRE
Alphafold ID
F8QN53
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: F8QN53
Sequence
MRILWIVAVCLIGVEGNLYQFGKMIRYKTGKSALLSYSDYGCYCGWGGQGKPKDATDRCC
FVHDCCYGRVNGCDPKLTIYSYSFENGDIVCGGDDSCKRAVCECDRVAAICFGENLNTYD
KKYKNYPSSQCTETEQC
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Sequence Length
137
Mass (Da)
15316
Signal Sequence
MRILWIVAVCLIGVEG
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Sequence Removed Signal Peptide
NLYQFGKMIRYKTGKSALLSYSDYGCYCGWGGQGKPKDATDRCCFVHDCCYGRVNGCDPK
LTIYSYSFENGDIVCGGDDSCKRAVCECDRVAAICFGENLNTYDKKYKNYPSSQCTETEQ
C
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Disulfide Bond
42-131;44-60;59-111;65-137;66-104;73-97;91-102
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Vipera
Species: Vipera renardi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR IC50
>100 μM
 . . [1], [2]
 Target Info    lymnaea stagnalis acetylcholine-binding protein (Ls-AChBP) IC50
>30 μM
 . . [1], [2]
 Target Info    nAChR alpha-7-similar IC50
>30 μM
 . . [1], [2]
 Target Info    nAChR alpha-7 IC50
29 μM
 . . [1], [2]
References
Ref 1 cDNA cloning, structural, and functional analyses of venom phospholipases A? and a Kunitz-type protease inhibitor from steppe viper Vipera ursinii renardi. Toxicon. 2011 Feb;57(2):332-41. doi: 10.1016/j.toxicon.2010.12.012. Epub 2010 Dec 23.
Ref 2 Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2. PLoS One. 2014 Dec 18;9(12):e115428. doi: 10.1371/journal.pone.0115428. eCollection 2014.
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