Target Information

General Information of This Target
Target ID
BTDT10114
Target Name
Nicotinic acetylcholine receptor (nAChR) alpha-2-beta-4
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Alpha-conotoxin MilIA IC50
>10 μM
 [1]
 Toxin Info    Alpha-conotoxin TxID IC50
4.55 μM
 [2], [3], [4], [5]
References
Ref 1 Structure-Function Elucidation of a New -Conotoxin, MilIA, from Conus milneedwardsi. Mar Drugs. 2019 Sep 16;17(9):535. doi: 10.3390/md17090535.
Ref 2 Characterization of a novel -conotoxin TxID from Conus textile that potently blocks rat 34 nicotinic acetylcholine receptors. J Med Chem. 2013 Dec 12;56(23):9655-63. doi: 10.1021/jm401254c. Epub 2013 Nov 22.
Ref 3 -Conotoxin [S9A]TxID Potently Discriminates between 34 and 6/34 Nicotinic Acetylcholine Receptors. J Med Chem. 2017 Jul 13;60(13):5826-5833. doi: 10.1021/acs.jmedchem.7b00546. Epub 2017 Jun 21.
Ref 4 Single Amino Acid Substitution in -Conotoxin TxID Reveals a Specific 34 Nicotinic Acetylcholine Receptor Antagonist. J Med Chem. 2018 Oct 25;61(20):9256-9265. doi: 10.1021/acs.jmedchem.8b00967. Epub 2018 Oct 9.
Ref 5 Effect of Methionine Oxidation and Substitution of -Conotoxin TxID on 34 Nicotinic Acetylcholine Receptor. Mar Drugs. 2018 Jun 20;16(6):215. doi: 10.3390/md16060215.
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