Peptide Information

General Information of This Peptide
Peptide ID
BTDP003723
Peptide Name
Alpha-conotoxin TxID
Symonym
Alpha-conotoxin TxIC
Species
Conus textile (Cloth-of-gold cone)
Uniprot Name
CA1D_CONTE
Alphafold ID
K8DWB5
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2M3I
Sequence
FDGRNAAGNDKMSALMALTTRGCCSHPVCSAMSPICG
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Sequence Length
37
Mass (Da)
3774
Sequence Removed Signal Peptide
FDGRNAAGNDKMSALMALTTRGCCSHPVCSAMSPICG
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Disulfide Bond
23-29;24-36
PDB ID
2M3I
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus textile
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-4 IC50
3.6 - 18.38 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-6/alpha-3-beta-4 IC50
33.9 - 94.1 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-2-beta-4 IC50
4.55 μM
 . . [1], [2], [3], [4]
References
Ref 1 Characterization of a novel -conotoxin TxID from Conus textile that potently blocks rat 34 nicotinic acetylcholine receptors. J Med Chem. 2013 Dec 12;56(23):9655-63. doi: 10.1021/jm401254c. Epub 2013 Nov 22.
Ref 2 -Conotoxin [S9A]TxID Potently Discriminates between 34 and 6/34 Nicotinic Acetylcholine Receptors. J Med Chem. 2017 Jul 13;60(13):5826-5833. doi: 10.1021/acs.jmedchem.7b00546. Epub 2017 Jun 21.
Ref 3 Single Amino Acid Substitution in -Conotoxin TxID Reveals a Specific 34 Nicotinic Acetylcholine Receptor Antagonist. J Med Chem. 2018 Oct 25;61(20):9256-9265. doi: 10.1021/acs.jmedchem.8b00967. Epub 2018 Oct 9.
Ref 4 Effect of Methionine Oxidation and Substitution of -Conotoxin TxID on 34 Nicotinic Acetylcholine Receptor. Mar Drugs. 2018 Jun 20;16(6):215. doi: 10.3390/md16060215.
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