Target Information

General Information of This Target
Target ID
BTDT10091
Target Name
Nicotinic acetylcholine receptor (nAChR) alpha-1-beta-1-delta-epsilon
Target Bioclass
Receptor
Taxonomy ID
9606
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Conorfamide-As2 IC50
208 nM
 [1]
 Toxin Info    Conorfamide-As1 IC50
215 nM
 [1]
 Toxin Info    Haditoxin IC50
550 nM
 [2], [3], [4]
 Toxin Info    Conorfamide-As2 IC50
707 nM
 [1]
 Toxin Info    Conorfamide-As1 IC50
820 nM
 [1]
References
Ref 1 Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochem Pharmacol. 2019 Jun;164:342-348. doi: 10.1016/j.bcp.2019.04.025. Epub 2019 Apr 24.
Ref 2 Beta-cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king cobra) venom with beta-blocker activity. FASEB J. 2007 Nov;21(13):3685-95. doi: 10.1096/fj.07-8658com. Epub 2007 Jul 6.
Ref 3 The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20651-6. doi: 10.1073/pnas.1314702110. Epub 2013 Dec 2.
Ref 4 Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (king cobra). J Biol Chem. 2010 Mar 12;285(11):8302-15. doi: 10.1074/jbc.M109.074161. Epub 2010 Jan 13.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.