Peptide Information

General Information of This Peptide
Peptide ID
BTDP005350
Peptide Name
Conorfamide-As2
Symonym
Conorfamide-As2a; Conorfamide-As2b
Species
Conus cancellatus (Cancellate cone) (Conus austini)
Uniprot Name
CRF2_CONCF
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
RIRKPIFAFPRF
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Sequence Length
12
Mass (Da)
1548
Sequence Removed Signal Peptide
RIRKPIFAFPRF
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus cancellatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    ASIC1a Effective concentration 50
10.9 μM
 . . [1]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
208 nM
 . . [1]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
707 nM
 . . [1]
 Target Info    nAChR alpha-7 IC50
0.689 - 3.867 μM
 . . [1]
 Target Info    nAChR alpha-7 IC50
20.971 - 70.036 μM
 . . [1]
References
Ref 1 Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochem Pharmacol. 2019 Jun;164:342-348. doi: 10.1016/j.bcp.2019.04.025. Epub 2019 Apr 24.
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