Target Information

General Information of This Target
Target ID
BTDT10059
Target Name
Glutamate receptor ionotropic, NMDA 2B
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Conantokin Rl-B IC50
0.1 μM
 [1], [2], [3]
 Toxin Info    Conopeptide-Ac1 IC50
8.22 μM
 [4], [5]
References
Ref 1 Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry. 2012 Jun 12;51(23):4685-92. doi: 10.1021/bi300055n. Epub 2012 May 30.
Ref 2 Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors. J Biol Chem. 2015 Jul 17;290(29):18156-18172. doi: 10.1074/jbc.M115.650341. Epub 2015 Jun 5.
Ref 3 Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. Biochemistry. 2016 Dec 27;55(51):7112-7122. doi: 10.1021/acs.biochem.6b00962. Epub 2016 Dec 16.
Ref 4 Novel conopeptides in a form of disulfide-crosslinked dimer. Peptides. 2010 Jun;31(6):1001-6. doi: 10.1016/j.peptides.2010.03.010. Epub 2010 Mar 20.
Ref 5 Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR. Mar Drugs. 2020 Feb 26;18(3):135. doi: 10.3390/md18030135.
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