Peptide Information

General Information of This Peptide
Peptide ID
BTDP004875
Peptide Name
Conantokin Rl-B
Symonym
Con Rl-B; ConRl-B
Species
Conus rolani (Cone snail)
Uniprot Name
CKR1B_CONRO
Alphafold ID
P0DKZ0
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MYZ
Sequence
MQLYTYLYLLVPLVTFHLILGTGTLDHGDALTERRSTDATALKPEPVLLQKSSARSTNDN
GKDTQMKRILKKRGNKARGEEELAEKAPEFARELAN
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Sequence Length
96
Mass (Da)
10756
Signal Sequence
MQLYTYLYLLVPLVTFHLILG
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Sequence Removed Signal Peptide
TGTLDHGDALTERRSTDATALKPEPVLLQKSSARSTNDNGKDTQMKRILKKRGNKARGEE
ELAEKAPEFARELAN
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PDB ID
2MYZ , 2MZK , 5TBG , 5TBQ , 5TBR
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus rolani
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    NR2B IC50
0.1 μM
 . . [1], [2], [3]
References
Ref 1 Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry. 2012 Jun 12;51(23):4685-92. doi: 10.1021/bi300055n. Epub 2012 May 30.
Ref 2 Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors. J Biol Chem. 2015 Jul 17;290(29):18156-18172. doi: 10.1074/jbc.M115.650341. Epub 2015 Jun 5.
Ref 3 Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. Biochemistry. 2016 Dec 27;55(51):7112-7122. doi: 10.1021/acs.biochem.6b00962. Epub 2016 Dec 16.
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